Virulence Factors and Azole-Resistant Mechanism of Candida Tropicalis Isolated from Candidemia

Limited knowledge exists on the virulence factors of Candida tropicalis and mechanisms azole resistance that lead to an intensified pathogenicity treatment failure. We aimed evaluate molecular among C. isolated from patients with candidemia. Several factors, including extracellular enzymatic activities, cell surface hydrophobicity (CSH), biofilm formation, were evaluated. Antifungal susceptibility pattern expression level ERG11, UPC2, MDR1, CDR1 genes eight (4 fluconazole 4 susceptible) clinical isolates assessed. The correlation between antifungal patterns was analyzed. During a year study, forty-five recovered candidemia patients. expressed different frequencies determinants as follows: coagulase (8.9%), phospholipase 5 (11.1%), proteinase 31 (68.9%), esterase 43 (95.6%), hemolysin 44 (97.8%), formation 45 (100%) CSH 45(100%). All susceptible amphotericin B showed highest voriconazole. There significant positive micafungin minimum inhibitory concentrations (MICs) production (rs = 0.316). However, we found negative MICs ?0.383). observed high ERG11 UPC2 in fluconazole-resistant isolates. extensively displayed capacities for hemolysis, activity, hydrophobicity. In addition, overexpression considered one possible resistance.